(2S)-2-( N-p-toluene-sulphonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one

Base Information

Chemical Name:(2S)-2-( N-p-toluene-sulphonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one
CAS No.:702702-11-2
Molecular Formula:C₃₀H₃₇N₃O₄SSi
Molecular Weight:563.793
Hs Code.:

Synonyms:(2S)-2-( N-p-toluene-sulphonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one

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Chemical Property of (2S)-2-( N-p-toluene-sulphonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one

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Technology Process of (2S)-2-( N-p-toluene-sulphonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one

There total 4 articles about (2S)-2-( N-p-toluene-sulphonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 3-(tert-butyl-diphenyl-silanyloxy)-2-(toluene-4-sulfonylamino)-propionyl chloride

: 764-43-2
diazobutane

: 702702-11-2
(2S)-2-( N-p-toluene-sulphonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;
DOI:10.1016/j.jorganchem.2005.07.016

Reference yield:

: 7663-92-5,5873-11-0,5873-13-2,5873-12-1
N-tosyl-L-serine

: 702702-11-2
(2S)-2-( N-p-toluene-sulphonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 36 h

2: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 20 °C

3: 45 percent / diethyl ether; tetrahydrofuran / 1 h / 0 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.jorganchem.2005.07.016

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 702702-11-2
(2S)-2-( N-p-toluene-sulphonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 36 h

2: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 20 °C

3: 45 percent / diethyl ether; tetrahydrofuran / 1 h / 0 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.jorganchem.2005.07.016