1-Diazobutane

Base Information

• Chemical Name: 1-Diazobutane
• CAS No.: 764-43-2
• Molecular Formula: C4H8N2
• Molecular Weight: 84.1209
• Mol file: 764-43-2.mol

Synonyms:

Chemical Property of 1-Diazobutane

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Diazobutane

There total 1 articles about 1-Diazobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-butyl-1-nitrosourea (869-01-2) → 1-butylene (106-98-9,9003-28-5) + diazobutane (764-43-2)

Guidance literature:

at 0 ℃;

Reference yield: 55.0%

diazobutane (764-43-2) + (S)-2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid (145790-51-8) → (2S)-2-(N-tert-butyloxycarbonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one (702702-09-8)

Guidance literature:

(S)-2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at -20 ℃;

diazobutane; In diethyl ether; at 0 - 20 ℃; Further stages.;

DOI:10.1016/j.tetlet.2004.03.036

Reference yield: 50.0%

C27H37NO7Si + diazobutane (764-43-2) → (2S)-2-(N-tert-butyloxycarbonyl)-amino-1-tert-butyldiphenylsilyloxy-4-diazo-heptan-3-one (702702-09-8)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h;

DOI:10.1016/j.jorganchem.2005.07.016

upstream raw materials:

1-butyl-1-nitrosourea

Downstream raw materials:

Butyraldehyd-butylhydrazon

phenyl butyl ketone

butyl p-nitrobenzoate

1-butyl (1-phenyl-1-methylethyl) peroxide

Refernces

Palladium-catalyzed cyclopropanation of alkenyl silanes by diazoalkanes: Evidence for a Pd⁰ mechanism

10.1002/chem.200802052

The study focuses on the palladium-catalyzed cyclopropanation of alkenyl silanes using diazoalkanes, exploring the mechanism and efficiency of this reaction in organic chemistry. The researchers used Pd(OAc)2 as a catalyst, diazomethane (CH2N2), diazoethane, and diazobutane as diazo compounds, and a variety of alkenyl silanes as substrates. The purpose of these chemicals was to investigate the formation of silyl cyclopropanes, assess the diastereoselectivity of the cyclopropanation, and gain insights into the active species and resting state of the catalyst. The study provides evidence for a Pd0 mechanism and suggests that a Pd0(alkenyl silane)3 complex is the resting state in the catalytic cycle. The findings have implications for the development of asymmetric versions of this reaction and contribute to the understanding of palladium-catalyzed cyclopropanation reactions.