N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt

Base Information

Chemical Name:N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt
CAS No.:1361970-37-7
Molecular Formula:C₉H₁₂O₃S*C₂₄H₂₈N₆O₅S
Molecular Weight:712.848
Hs Code.:

N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt

Synonyms:N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt

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Chemical Property of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt

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Technology Process of N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt

There total 17 articles about N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1361970-37-7
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol / 2.75 h / 0 - 10 °C / Industry scale; Inert atmosphere

2.1: hydrogenchloride; iron / ethanol; water / 23 h / 10 - 25 °C / Industry scale; Inert atmosphere

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

4.1: pyridine / 18 h / 20 °C

5.1: potassium phosphate; potassium hydrogenfluoride / tricyclohexylphosphine; palladium diacetate / isopropyl alcohol; water / 2 h / 75 - 80 °C / Inert atmosphere

6.1: sodium hydroxide; water / 3.08 h / 17 - 23 °C

6.2: 30 °C / pH 6.6

7.1: tetrahydrofuran / 20 °C

With pyridine; hydrogenchloride; potassium phosphate; potassium hydrogenfluoride; water; potassium acetate; iron; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; isopropyl alcohol;

Reference yield:

: 3453-83-6
mesitylene sulfonic acid

: 1254036-66-2
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

: 1361970-37-7
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 152684-30-5
5-bromo-2-methoxy-3-nitropyridine

: 1361970-37-7
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide mesitylenesulfonate salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; iron / ethanol; water / 23 h / 10 - 25 °C / Industry scale; Inert atmosphere

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3.1: pyridine / 18 h / 20 °C

4.1: potassium phosphate; potassium hydrogenfluoride / tricyclohexylphosphine; palladium diacetate / isopropyl alcohol; water / 2 h / 75 - 80 °C / Inert atmosphere

5.1: sodium hydroxide; water / 3.08 h / 17 - 23 °C

5.2: 30 °C / pH 6.6

6.1: tetrahydrofuran / 20 °C

With pyridine; hydrogenchloride; potassium phosphate; potassium hydrogenfluoride; water; potassium acetate; iron; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; water; isopropyl alcohol;