MethanesulfonaMide, N-[5-[4-[5-[[(2R,6S)-2,6-diMethyl-4-Morpholinyl]Methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-Methoxy-3-pyridinyl]-, rel-

Base Information

Chemical Name:MethanesulfonaMide, N-[5-[4-[5-[[(2R,6S)-2,6-diMethyl-4-Morpholinyl]Methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-Methoxy-3-pyridinyl]-, rel-
CAS No.:1254036-66-2
Molecular Formula:C₂₄H₂₈N₆O₅S
Molecular Weight:512.59
Hs Code.:
Mol file:1254036-66-2.mol

Synonyms:N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

Suppliers and Price of MethanesulfonaMide, N-[5-[4-[5-[[(2R,6S)-2,6-diMethyl-4-Morpholinyl]Methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-Methoxy-3-pyridinyl]-, rel-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rel-N-[5-[4-[5-[[(2R,6S)-2,6-Dimethyl-4-morpholinyl]methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-methoxy-3-pyridinyl]methanesulfonamide
1mg
$ 45.00

DC Chemicals
PI3KδinhibitorGS2292767 >98%
1 g
$ 3500.00

DC Chemicals
PI3KδinhibitorGS2292767 >98%
250 mg
$ 1750.00

Cayman Chemical
GSK2292767 ≥98%
1mg
$ 35.00

Cayman Chemical
GSK2292767 ≥98%
5mg
$ 166.00

Cayman Chemical
GSK2292767 ≥98%
25mg
$ 656.00

Cayman Chemical
GSK2292767 ≥98%
10mg
$ 298.00

ApexBio Technology
GSK2292767
10mg
$ 414.00

ApexBio Technology
GSK2292767
25mg
$ 909.00

ApexBio Technology
GSK2292767
5mg
$ 230.00

Total 12 raw suppliers

Chemical Property of MethanesulfonaMide, N-[5-[4-[5-[[(2R,6S)-2,6-diMethyl-4-Morpholinyl]Methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-Methoxy-3-pyridinyl]-, rel-

Chemical Property:

Melting Point:199-202°C
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

rel-N-[5-[4-[5-[[(2R,6S)-2,6-Dimethyl-4-morpholinyl]methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-methoxy-3-pyridinyl]methanesulfonamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses rel-N-[5-[4-[5-[[(2R,6S)-2,6-Dimethyl-4-morpholinyl]methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-methoxy-3-pyridinyl]methanesulfonamide is a selective PI3Kδ inhibitor for the treatment of respiratory disease (1,2).

Technology Process of MethanesulfonaMide, N-[5-[4-[5-[[(2R,6S)-2,6-diMethyl-4-Morpholinyl]Methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-Methoxy-3-pyridinyl]-, rel-

There total 1 articles about MethanesulfonaMide, N-[5-[4-[5-[[(2R,6S)-2,6-diMethyl-4-Morpholinyl]Methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-Methoxy-3-pyridinyl]-, rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1254036-66-2
N-[5-[4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1H-indazol-6-yl]-2-(methyloxy)-3-pyridinyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 2.75 h / 0 - 10 °C / Industry scale; Inert atmosphere

2.1: hydrogenchloride; iron / ethanol; water / 23 h / 10 - 25 °C / Industry scale; Inert atmosphere

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

4.1: pyridine / 18 h / 20 °C

5.1: potassium phosphate; potassium hydrogenfluoride / tricyclohexylphosphine; palladium diacetate / isopropyl alcohol; water / 2 h / 75 - 80 °C / Inert atmosphere

6.1: sodium hydroxide; water / 3.08 h / 17 - 23 °C

6.2: 30 °C / pH 6.6

With pyridine; hydrogenchloride; potassium phosphate; potassium hydrogenfluoride; water; potassium acetate; iron; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; tricyclohexylphosphine; In 1,4-dioxane; methanol; ethanol; water; isopropyl alcohol;