5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-(2-trimethylsilylethyl)-2'-deoxyinosine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-(2-trimethylsilylethyl)-2'-deoxyinosine
CAS No.:175730-59-3
Molecular Formula:C₃₆H₄₁FN₄O₆Si
Molecular Weight:672.829
Hs Code.:

5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O<sup>6</sup>-(2-trimethylsilylethyl)-2'-deoxyinosine

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-(2-trimethylsilylethyl)-2'-deoxyinosine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-(2-trimethylsilylethyl)-2'-deoxyinosine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-(2-trimethylsilylethyl)-2'-deoxyinosine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-(2-trimethylsilylethyl)-2'-deoxyinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 151900-41-3
6-(2-(trimethylsilyl)ethoxy)-2-fluoropurine-9-(2'-deoxyriboside)

: 175730-59-3
5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-(2-trimethylsilylethyl)-2'-deoxyinosine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In pyridine; at 10 ℃; for 15h; argon atmosphere;
DOI:10.1021/tx9501795

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 175730-59-3
5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-(2-trimethylsilylethyl)-2'-deoxyinosine

Guidance literature:: Multi-step reaction with 4 steps

1: Ph₃P; diethyl azodicargoxylate / dioxane / 0.33 h / 100 °C / argon atmosphere

2: 89 percent / NaOMe / methanol / 7 h / 20 °C / argon atmosphere

3: 95 percent / HF/pyridine; t-butyl nitrite / 0.83 h / -40 - -35 °C / argon atmosphere

4: 84 percent / diisopropylethylamine / pyridine / 15 h / 10 °C / argon atmosphere

With pyridine; tert.-butylnitrite; hydrogen fluoride; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; pyridine; methanol; 1: Mitsunobu condensation / 2: Deacetylation / 3: Substitution / 4: Alkylation;
DOI:10.1021/tx9501795

Reference yield:

: 4318-05-2
2-(acetylamino)-9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one

: 175730-59-3
5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-(2-trimethylsilylethyl)-2'-deoxyinosine

Guidance literature:: Multi-step reaction with 4 steps

1: Ph₃P; diethyl azodicargoxylate / dioxane / 0.33 h / 100 °C / argon atmosphere

2: 89 percent / NaOMe / methanol / 7 h / 20 °C / argon atmosphere

3: 95 percent / HF/pyridine; t-butyl nitrite / 0.83 h / -40 - -35 °C / argon atmosphere

4: 84 percent / diisopropylethylamine / pyridine / 15 h / 10 °C / argon atmosphere

With pyridine; tert.-butylnitrite; hydrogen fluoride; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; pyridine; methanol; 1: Mitsunobu condensation / 2: Deacetylation / 3: Substitution / 4: Alkylation;
DOI:10.1021/tx9501795