4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (4-fluorophenyl) carbonate

Base Information

• Chemical Name: 4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (4-fluorophenyl) carbonate
• CAS No.: 1312807-99-0
• Molecular Formula: C₂₄H₁₈FNO₅
• Molecular Weight: 419.409
• Mol file: 1312807-99-0.mol

Synonyms:4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (4-fluorophenyl) carbonate

Chemical Property of 4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (4-fluorophenyl) carbonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (4-fluorophenyl) carbonate

There total 1 articles about 4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (4-fluorophenyl) carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-fluorophenyl chloroformate (38377-38-7) + 4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole (217446-35-0) → 4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (4-fluorophenyl) carbonate (1312807-99-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 16.5h;

DOI:10.1039/c1ob05160a

Reference yield: 31.0%

4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (4-fluorophenyl) carbonate (1312807-99-0) → 4-fluorophenyl 4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate (1312808-02-8)

Guidance literature:

With 2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1039/c1ob05160a

Reference yield:

4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl (4-fluorophenyl) carbonate (1312807-99-0) → C24H18FNO5

Guidance literature:

With (S)-2,6-dimethoxy-4-(pyridin-4-yl)-4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]azepine; In diethyl ether; at -60 ℃; for 12h; enantioselective reaction;

upstream raw materials:

4-fluorophenyl chloroformate

4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole

Downstream raw materials:

4-fluorophenyl 4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate