1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate
CAS No.:1052696-07-7
Molecular Formula:C₂₅H₂₈ClN₅O₃S
Molecular Weight:514.048
Hs Code.:

Synonyms:1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Suppliers and Price of 1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

There total 5 articles about 1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1052696-06-6
5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-amine

: 170097-67-3
2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

: 1052696-07-7
1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 95-51-2
o-chloroaniline

: 1052696-07-7
1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -50 - 20 °C

1.2: 5.5 h / -50 - 20 °C

2.1: acetonitrile / 0.5 h / 20 °C

2.2: 2 h / 20 - 40 °C

2.3: 1 h

3.1: N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3.2: 2 h / 20 °C

4.1: methanesulfonyl chloride / toluene / 3 h / Heating / reflux

4.2: pH 8

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

With n-butyllithium; methanesulfonyl chloride; triethylamine; HATU; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1052696-04-4
N-(2-chlorophenyl)-N-methylglycine

: 1052696-07-7
1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

1.2: 2 h / 20 °C

2.1: methanesulfonyl chloride / toluene / 3 h / Heating / reflux

2.2: pH 8

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

With methanesulfonyl chloride; triethylamine; HATU; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; toluene;