N-(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Base Information

Chemical Name:N-(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride
CAS No.:1052693-60-3
Molecular Formula:C₂₀H₂₀ClN₅OS*ClH
Molecular Weight:450.392
Hs Code.:

Synonyms:N-(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Suppliers and Price of N-(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

There total 6 articles about N-(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1052696-07-7
1,1-dimethylethyl 6-{[(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

: 1052693-60-3
N-(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃;

Reference yield:

: 95-51-2
o-chloroaniline

: 1052693-60-3
N-(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -50 - 20 °C

1.2: 5.5 h / -50 - 20 °C

2.1: acetonitrile / 0.5 h / 20 °C

2.2: 2 h / 20 - 40 °C

2.3: 1 h

3.1: N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3.2: 2 h / 20 °C

4.1: methanesulfonyl chloride / toluene / 3 h / Heating / reflux

4.2: pH 8

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

6.1: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; n-butyllithium; methanesulfonyl chloride; triethylamine; HATU; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1052696-04-4
N-(2-chlorophenyl)-N-methylglycine

: 1052693-60-3
N-(5-{[(2-chlorophenyl)(methyl)amino]methyl}-1,3,4-thiadiazol-2-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

1.2: 2 h / 20 °C

2.1: methanesulfonyl chloride / toluene / 3 h / Heating / reflux

2.2: pH 8

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

4.1: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; methanesulfonyl chloride; triethylamine; HATU; N,N-dimethyl-formamide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;