methyl 5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methoxy-2-nitrobenzoate

Base Information

Chemical Name:methyl 5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methoxy-2-nitrobenzoate
CAS No.:1310878-69-3
Molecular Formula:C₂₅H₂₇NO₇Si
Molecular Weight:481.577
Hs Code.:

Synonyms:methyl 5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methoxy-2-nitrobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methoxy-2-nitrobenzoate

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Technology Process of methyl 5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methoxy-2-nitrobenzoate

There total 2 articles about methyl 5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methoxy-2-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1100771-88-7
methyl 3,5-dihydroxy-4-methoxy-2-nitro-benzoate

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1310878-69-3
methyl 5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methoxy-2-nitrobenzoate

Guidance literature:: With 2,6-dimethylpyridine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 2h; Cooling with ice; Inert atmosphere;
DOI:10.1002/anie.201100981

Reference yield:

: 24093-81-0
methyl 3,5-dihydroxy-4-methoxybenzoate

: 1310878-69-3
methyl 5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methoxy-2-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: nitric acid / water; acetic acid / 0.75 h / 20 °C

2: 2,6-dimethylpyridine / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 20 °C / Cooling with ice; Inert atmosphere

With 2,6-dimethylpyridine; nitric acid; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/anie.201100981

Reference yield: 96.0%

: 1310878-69-3
methyl 5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methoxy-2-nitrobenzoate

: 77-78-1
dimethyl sulfate

: 1310878-85-3
methyl 5-(tert-butyldiphenylsilyloxy)-3,4-dimethoxy-2-nitrobenzoate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Cooling with ice; Inert atmosphere;
DOI:10.1002/anie.201100981