Technology Process of 5-((E)-2-(ethoxycarbonyl)vinyl)-2,3-dimethoxy-4-nitrophenyl methanesulfonate
There total 7 articles about 5-((E)-2-(ethoxycarbonyl)vinyl)-2,3-dimethoxy-4-nitrophenyl methanesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.33 h / 20 °C / Inert atmosphere; Molecular sieve
2: toluene / 0.33 h / 20 °C / Inert atmosphere
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
dichloromethane; toluene;
2: Wittig reaction;
DOI:10.1002/anie.201100981
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1.5 h / 20 °C / Cooling with ice; Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.42 h / 20 °C / Inert atmosphere
3: triethylamine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
4: diisobutylaluminium hydride / dichloromethane; toluene / 0.92 h / -78 °C / Inert atmosphere
5: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.33 h / 20 °C / Inert atmosphere; Molecular sieve
6: toluene / 0.33 h / 20 °C / Inert atmosphere
With
tetrapropylammonium perruthennate; potassium tert-butylate; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
6: Wittig reaction;
DOI:10.1002/anie.201100981
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere
2: diisobutylaluminium hydride / dichloromethane; toluene / 0.92 h / -78 °C / Inert atmosphere
3: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.33 h / 20 °C / Inert atmosphere; Molecular sieve
4: toluene / 0.33 h / 20 °C / Inert atmosphere
With
tetrapropylammonium perruthennate; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine;
In
dichloromethane; toluene;
4: Wittig reaction;
DOI:10.1002/anie.201100981
