(RS)-S-(4-{[4-{[(R)-2-hydroxy-1,2-dimethylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]-amino}phenyl)-S-methylsulfoximide

Base Information

Chemical Name:(RS)-S-(4-{[4-{[(R)-2-hydroxy-1,2-dimethylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]-amino}phenyl)-S-methylsulfoximide
CAS No.:1223498-29-0
Molecular Formula:C₁₇H₂₁F₃N₄O₃S
Molecular Weight:418.44
Hs Code.:

Synonyms:(RS)-S-(4-{[4-{[(R)-2-hydroxy-1,2-dimethylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]-amino}phenyl)-S-methylsulfoximide

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Chemical Property of (RS)-S-(4-{[4-{[(R)-2-hydroxy-1,2-dimethylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]-amino}phenyl)-S-methylsulfoximide

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Technology Process of (RS)-S-(4-{[4-{[(R)-2-hydroxy-1,2-dimethylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]-amino}phenyl)-S-methylsulfoximide

There total 7 articles about (RS)-S-(4-{[4-{[(R)-2-hydroxy-1,2-dimethylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]-amino}phenyl)-S-methylsulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₀F₆N₄O₄S

: 1223498-29-0
(RS)-S-(4-{[4-{[(R)-2-hydroxy-1,2-dimethylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]-amino}phenyl)-S-methylsulfoximide

Guidance literature:: With potassium carbonate; at 20 ℃; for 1.5h;

Reference yield:

: 22133-01-3
S-methyl-S-(4-nitrophenyl)sulfoximine

: 1223498-29-0
(RS)-S-(4-{[4-{[(R)-2-hydroxy-1,2-dimethylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]-amino}phenyl)-S-methylsulfoximide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 2 h / cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / di-isopropyl ether; ethanol; tetrahydrofuran / 0.75 h / 24 °C / 760.05 Torr

3.1: ethanol / 6 h / 70 °C

3.2: 1.5 h / 20 °C

4.1: potassium carbonate / 1.5 h / 20 °C

With dmap; hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; di-isopropyl ether;

Reference yield:

: 940-12-5
p-nitrophenyl methyl sulfoxide

: 1223498-29-0
(RS)-S-(4-{[4-{[(R)-2-hydroxy-1,2-dimethylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]-amino}phenyl)-S-methylsulfoximide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide; sulfuric acid / dichloromethane / 16 h / 0 - 45 °C

1.2: pH 11

2.1: dmap; triethylamine / dichloromethane / 2 h / cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / di-isopropyl ether; ethanol; tetrahydrofuran / 0.75 h / 24 °C / 760.05 Torr

4.1: ethanol / 6 h / 70 °C

4.2: 1.5 h / 20 °C

5.1: potassium carbonate / 1.5 h / 20 °C

With dmap; sodium azide; sulfuric acid; hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; di-isopropyl ether;