2-allyl-3-methyl-1-phenyl-1-butanone

Base Information

• Chemical Name: 2-allyl-3-methyl-1-phenyl-1-butanone
• CAS No.: 1381862-35-6
• Molecular Formula: C₁₄H₁₈O
• Molecular Weight: 202.296
• Mol file: 1381862-35-6.mol

Synonyms:2-allyl-3-methyl-1-phenyl-1-butanone

Chemical Property of 2-allyl-3-methyl-1-phenyl-1-butanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-allyl-3-methyl-1-phenyl-1-butanone

There total 2 articles about 2-allyl-3-methyl-1-phenyl-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-allyl 3-methyl-1-phenyl-1-butenyl carbonate → 2-allyl-3-methyl-1-phenyl-1-butanone + 2-allyl-3-methyl-1-phenyl-1-butanone (1381862-35-6)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; (R,R)-ANDEN-phenyl Trost ligand; In 1,4-dioxane; at 20 ℃; for 24h; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja9053948

Reference yield:

3-methyl-1-phenylbutan-1-one (582-62-7) → 2-allyl-3-methyl-1-phenyl-1-butanone (1381862-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,4,6-tri-tert-butylphenoxol; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,4,6-tri-tert-butylphenoxol; potassium hexamethylsilazane; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol; In tetrahydrofuran; toluene;

DOI:10.1021/ol301332f

Reference yield: 84.0%

2-allyl-3-methyl-1-phenyl-1-butanone (1381862-35-6) → (S)-3-benzoyl-4-methylpentanal (1381862-27-6)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In water; ethyl acetate; Inert atmosphere;

DOI:10.1021/ol301332f

upstream raw materials:

3-methyl-1-phenylbutan-1-one

Downstream raw materials:

(S)-3-benzoyl-4-methylpentanal