(S)-3-benzoyl-4-methylpentanal

Base Information

• Chemical Name: (S)-3-benzoyl-4-methylpentanal
• CAS No.: 1381862-27-6
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.269
• Mol file: 1381862-27-6.mol

Synonyms:(S)-3-benzoyl-4-methylpentanal

Chemical Property of (S)-3-benzoyl-4-methylpentanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-benzoyl-4-methylpentanal

There total 5 articles about (S)-3-benzoyl-4-methylpentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-allyl-3-methyl-1-phenyl-1-butanone (1381862-35-6) → (S)-3-benzoyl-4-methylpentanal (1381862-27-6)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In water; ethyl acetate; Inert atmosphere;

DOI:10.1021/ol301332f

Reference yield:

(Z)-allyl 3-methyl-1-phenyl-1-butenyl carbonate → (S)-3-benzoyl-4-methylpentanal (1381862-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,4,6-tri-tert-butylphenoxol; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2: sodium periodate; osmium(VIII) oxide / water; ethyl acetate / Inert atmosphere

With sodium periodate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; osmium(VIII) oxide; 2,4,6-tri-tert-butylphenoxol; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol; In tetrahydrofuran; water; ethyl acetate;

DOI:10.1021/ol301332f

Reference yield:

3-methyl-1-phenylbutan-1-one (582-62-7) → (S)-3-benzoyl-4-methylpentanal (1381862-27-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,4,6-tri-tert-butylphenoxol; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: sodium periodate; osmium(VIII) oxide / water; ethyl acetate / Inert atmosphere

With sodium periodate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; osmium(VIII) oxide; 2,4,6-tri-tert-butylphenoxol; potassium hexamethylsilazane; (S)-4-tert-butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazol; In tetrahydrofuran; water; ethyl acetate; toluene;

DOI:10.1021/ol301332f

upstream raw materials:

2-allyl-3-methyl-1-phenyl-1-butanone

3-methyl-1-phenylbutan-1-one

(E)-4-methylpent-2-enal

phenylglyoxal hydrate