(E)-(4R,5R,11R)-5-(tert-butyldiphenylsilyloxy)-11-hydroxy-4-((2-methoxyethoxy)methoxy)-2-dodecenoic acid

Base Information

Chemical Name:(E)-(4R,5R,11R)-5-(tert-butyldiphenylsilyloxy)-11-hydroxy-4-((2-methoxyethoxy)methoxy)-2-dodecenoic acid
CAS No.:1107608-23-0
Molecular Formula:C₃₂H₄₈O₇Si
Molecular Weight:572.814
Hs Code.:

Synonyms:(E)-(4R,5R,11R)-5-(tert-butyldiphenylsilyloxy)-11-hydroxy-4-((2-methoxyethoxy)methoxy)-2-dodecenoic acid

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Chemical Property of (E)-(4R,5R,11R)-5-(tert-butyldiphenylsilyloxy)-11-hydroxy-4-((2-methoxyethoxy)methoxy)-2-dodecenoic acid

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Technology Process of (E)-(4R,5R,11R)-5-(tert-butyldiphenylsilyloxy)-11-hydroxy-4-((2-methoxyethoxy)methoxy)-2-dodecenoic acid

There total 1 articles about (E)-(4R,5R,11R)-5-(tert-butyldiphenylsilyloxy)-11-hydroxy-4-((2-methoxyethoxy)methoxy)-2-dodecenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1107608-22-9
(E)-(4R,5R,11R)-methyl 11-acetoxy-5-(tert-butyldiphenylsilyloxy)-4-((2-methoxyethoxy)methoxy)-2-dodecenoate

: 1107608-23-0
(E)-(4R,5R,11R)-5-(tert-butyldiphenylsilyloxy)-11-hydroxy-4-((2-methoxyethoxy)methoxy)-2-dodecenoic acid

Guidance literature:: (E)-(4R,5R,11R)-methyl 11-acetoxy-5-(tert-butyldiphenylsilyloxy)-4-((2-methoxyethoxy)methoxy)-2-dodecenoate; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; pH=4;
DOI:10.1016/j.tet.2008.10.059

Reference yield: 73.0%

: 1107608-23-0
(E)-(4R,5R,11R)-5-(tert-butyldiphenylsilyloxy)-11-hydroxy-4-((2-methoxyethoxy)methoxy)-2-dodecenoic acid

: 1107608-24-1
(E)-(5R,6R,12R)-6-(tert-butyldiphenylsilyloxy)-5-((2-methoxyethoxy)methoxy)-12-methyloxacyclododec-3-en-2-one

Guidance literature:: (E)-(4R,5R,11R)-5-(tert-butyldiphenylsilyloxy)-11-hydroxy-4-((2-methoxyethoxy)methoxy)-2-dodecenoic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

With dmap; In tetrahydrofuran; toluene; for 3h; Reflux;
DOI:10.1016/j.tet.2008.10.059