1,3-dimethyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Base Information

• Chemical Name: 1,3-dimethyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
• CAS No.: 1614252-39-9
• Molecular Formula: C₂₉H₂₇N₃O₂S
• Molecular Weight: 481.618
• Mol file: 1614252-39-9.mol

Synonyms:1,3-dimethyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Chemical Property of 1,3-dimethyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dimethyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

There total 3 articles about 1,3-dimethyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1396807-57-0) + (2-chloroethyl)(trityl)sulfane (108418-96-8) → 1,3-dimethyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1614252-39-9)

Guidance literature:

With caesium carbonate; potassium iodide; In N,N-dimethyl acetamide; at 50 ℃; for 41.7h; Inert atmosphere;

Reference yield:

trityl chloride (76-83-5) → 1,3-dimethyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1614252-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 22 h / 20 °C / Inert atmosphere

2: potassium iodide; caesium carbonate / N,N-dimethyl acetamide / 41.7 h / 50 °C / Inert atmosphere

With caesium carbonate; potassium iodide; In dichloromethane; N,N-dimethyl acetamide;

Reference yield:

1,3-dimethyluracil (874-14-6,156398-76-4) → 1,3-dimethyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1614252-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / 2-methyltetrahydrofuran / 0.67 h / 0 - 30 °C / Inert atmosphere

2: potassium iodide; caesium carbonate / N,N-dimethyl acetamide / 41.7 h / 50 °C / Inert atmosphere

With potassium tert-butylate; caesium carbonate; potassium iodide; In 2-methyltetrahydrofuran; N,N-dimethyl acetamide;

upstream raw materials:

trityl chloride

1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

(2-chloroethyl)(trityl)sulfane

1,3-dimethyluracil

Downstream raw materials:

3-(6-(2-mercaptoethyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

3-(10-(5-chlorofuran-2-yl)-1,3-dimethyl-2,4-dioxo-2,3,4,7,8,10-hexahydro-1H-pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]thiazin-5-yl)benzonitrile

1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-ylboronic acid

3-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile