ethyl 2-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)thiazole-4-carboxylate

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Chemical Name:ethyl 2-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)thiazole-4-carboxylate
CAS No.:1614252-42-4
Molecular Formula:C₃₅H₃₂N₄O₄S₂
Molecular Weight:636.795
Hs Code.:

Synonyms:ethyl 2-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)thiazole-4-carboxylate

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Chemical Property of ethyl 2-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)thiazole-4-carboxylate

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Technology Process of ethyl 2-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)thiazole-4-carboxylate

There total 6 articles about ethyl 2-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100367-77-9
ethyl 2-bromothiazole-4-carboxylate

: 1614252-38-8
1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-ylboronic acid

: 1614252-42-4
ethyl 2-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)thiazole-4-carboxylate

Guidance literature:: With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium hydrogencarbonate; In acetic acid butyl ester; water; at 80 ℃; for 21h;

Reference yield:

: 108418-96-8
(2-chloroethyl)(trityl)sulfane

: 1614252-42-4
ethyl 2-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium iodide; caesium carbonate / N,N-dimethyl acetamide / 41.7 h / 50 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C

3.1: sodium hydrogencarbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / acetic acid butyl ester; water / 21 h / 80 °C

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium hydrogencarbonate; caesium carbonate; potassium iodide; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl acetamide; acetic acid butyl ester; water;

Reference yield:

: 1614252-39-9
1,3-dimethyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1614252-42-4
ethyl 2-(1,3-dimethyl-2,4-dioxo-6-(2-(tritylthio)ethyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C

2.1: sodium hydrogencarbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / acetic acid butyl ester; water / 21 h / 80 °C

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; acetic acid butyl ester; water;