1-Pyrrolidinecarboxylic acid, 2-(3-ethoxy-3-oxo-1-propenyl)-, phenylmethyl ester, [R-(E)]-

Base Information Edit

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-(3-ethoxy-3-oxo-1-propenyl)-, phenylmethyl ester, [R-(E)]-
CAS No.:146727-84-6
Molecular Formula:C₁₇H₂₁NO₄
Molecular Weight:303.358
Hs Code.:
DSSTox Substance ID:DTXSID801121598
Mol file:146727-84-6.mol

Synonyms:ghl.PD_Mitscher_leg0.218;DTXSID801121598;146727-84-6;1-Pyrrolidinecarboxylic acid, 2-(3-ethoxy-3-oxo-1-propenyl)-, phenylmethyl ester, [R-(E)]-

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-(3-ethoxy-3-oxo-1-propenyl)-, phenylmethyl ester, [R-(E)]- Edit

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:303.14705815
Heavy Atom Count:22
Complexity:402

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C=CC1CCCN1C(=O)OCC2=CC=CC=C2
Isomeric SMILES:CCOC(=O)/C=C/[C@H]1CCCN1C(=O)OCC2=CC=CC=C2

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-(3-ethoxy-3-oxo-1-propenyl)-, phenylmethyl ester, [R-(E)]-

There total 7 articles about 1-Pyrrolidinecarboxylic acid, 2-(3-ethoxy-3-oxo-1-propenyl)-, phenylmethyl ester, [R-(E)]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 50463-82-6,71461-30-8,105706-84-1,143393-11-7
(2R)-(+)-phenylmethyl 2-formylpyrrolidine-1-carboxylate

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 146727-84-6
benzyl (2R)-2-((1E)-3-ethoxy-3-oxoprop-1-enyl)pyrrolidine-1-carboxylate

Guidance literature:: DOI:10.1016/S0040-4039(00)74703-4

Reference yield:

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 50463-82-6,71461-30-8,105706-84-1,143393-11-7
(2R)-(+)-phenylmethyl 2-formylpyrrolidine-1-carboxylate

: benzyl (2R)-2-((1Z)-3-ethoxy-3-oxoprop-1-enyl)pyrrolidine-1-carboxylate

: 146727-84-6
benzyl (2R)-2-((1E)-3-ethoxy-3-oxoprop-1-enyl)pyrrolidine-1-carboxylate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 0.416667h;

(2R)-(+)-phenylmethyl 2-formylpyrrolidine-1-carboxylate; In tetrahydrofuran; hexane; at 20 ℃; for 8.08333h;