methyl 4-(5-(4-hydroxy-2-(pyridin-2-yl )pyrimidin-5-yl)isoxazol-3-yl)benzoate

Base Information

• Chemical Name: methyl 4-(5-(4-hydroxy-2-(pyridin-2-yl )pyrimidin-5-yl)isoxazol-3-yl)benzoate
• CAS No.: 1428527-79-0
• Molecular Formula: C₂₀H₁₄N₄O₄
• Molecular Weight: 374.356
• Mol file: 1428527-79-0.mol

Synonyms:methyl 4-(5-(4-hydroxy-2-(pyridin-2-yl )pyrimidin-5-yl)isoxazol-3-yl)benzoate

Chemical Property of methyl 4-(5-(4-hydroxy-2-(pyridin-2-yl )pyrimidin-5-yl)isoxazol-3-yl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(5-(4-hydroxy-2-(pyridin-2-yl )pyrimidin-5-yl)isoxazol-3-yl)benzoate

There total 9 articles about methyl 4-(5-(4-hydroxy-2-(pyridin-2-yl )pyrimidin-5-yl)isoxazol-3-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-(5-(4-(4-methoxybenzyloxy)-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)benzoate (1428527-78-9) → methyl 4-(5-(4-hydroxy-2-(pyridin-2-yl )pyrimidin-5-yl)isoxazol-3-yl)benzoate (1428527-79-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

methyl 4-formylbenzoate (1571-08-0) → methyl 4-(5-(4-hydroxy-2-(pyridin-2-yl )pyrimidin-5-yl)isoxazol-3-yl)benzoate (1428527-79-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran; water / 20 °C

2: N-chloro-succinimide / chloroform / 4 h / 20 °C

3: triethylamine / tetrahydrofuran / 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; water;

Reference yield:

2-(pyridin-2-yl)-5-((trimethylsilyl)ethynyl)pyrimidin-4-ol (1428527-76-7) → methyl 4-(5-(4-hydroxy-2-(pyridin-2-yl )pyrimidin-5-yl)isoxazol-3-yl)benzoate (1428527-79-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 80 °C

2: triethylamine / tetrahydrofuran / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

methyl 4-formylbenzoate

4-(hydroxyiminomethyl)benzoic acid methyl ester

4-methoxycarbonylbenzhydroxamic acid chloride

methyl 2-(methoxymethylene)-4-(trimethylsilyl)but-3-ynoate

Downstream raw materials:

4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)benzoic acid