methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate

Base Information

• Chemical Name: methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate
• CAS No.: 1596354-59-4
• Molecular Formula: C₁₇H₁₁F₂NO₂
• Molecular Weight: 299.277
• Mol file: 1596354-59-4.mol

Synonyms:methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate

Chemical Property of methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate

There total 2 articles about methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluoro-1H-indole-2,3-dione (443-69-6) → methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate (1596354-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 18 h / Reflux

2: potassium carbonate / acetone / 5 h / Reflux

With potassium carbonate; potassium hydroxide; In ethanol; acetone; 1: |Pfitzinger Quinoline Synthesis;

DOI:10.1016/j.jfluchem.2014.02.012

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate (1596354-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 18 h / Reflux

2: potassium carbonate / acetone / 5 h / Reflux

With potassium carbonate; potassium hydroxide; In ethanol; acetone; 1: |Pfitzinger Quinoline Synthesis;

DOI:10.1016/j.jfluchem.2014.02.012

Reference yield: 75.0%

methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate (1596354-59-4) → 6-fluoro-2-(4-fluorophenyl)quinoline-4-carbohydrazide (1306588-39-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 7h; Reflux;

DOI:10.1016/j.jfluchem.2014.02.012

upstream raw materials:

5-fluoro-1H-indole-2,3-dione

1-(4-fluorophenyl)ethanone

Downstream raw materials:

6-fluoro-2-(4-fluorophenyl)-4-(5,6-diphenyl-1,2,4-triazin-3-yl)quinoline

6-fluoro-2-(4-fluorophenyl)quinoline-4-carbohydrazide

N-(4-chlorophenyl)-5-(6-fluoro-2-(4-fluorophenyl)quinolin-4-yl)-4H-1,2,4-triazol-3-amine

N-(4-bromophenyl)-5-(6-fluoro-2-(4-fluorophenyl)quinolin-4-yl)-4H-1,2,4-triazol-3-amine