1306588-39-5

Basic information

• Product Name: 6-fluoro-2-(4-fluorophenyl)quinoline-4-carbohydrazide
• Synonyms: 6-fluoro-2-(4-fluorophenyl)quinoline-4-carbohydrazide
• CAS NO: 1306588-39-5
• Molecular Weight: 299.28
• Mol File: 1306588-39-5.mol

Chemical Properties

• CAS DataBase Reference: 6-fluoro-2-(4-fluorophenyl)quinoline-4-carbohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-2-(4-fluorophenyl)quinoline-4-carbohydrazide(1306588-39-5)
• EPA Substance Registry System: 6-fluoro-2-(4-fluorophenyl)quinoline-4-carbohydrazide(1306588-39-5)

Safety Data

• Hazardous Substances Data: 1306588-39-5(Hazardous Substances Data)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 1543-31-3 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylic acid 
• 1596354-59-4 methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate 

Downstream Products

• 1596354-74-3 4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol 
• 1596354-75-4 3-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole-6-thiol 
• 1596354-73-2 N-(2,5-dimethyl-1H-pyrrol-1-yl)-6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxamide 
• 1306588-48-6 5-(2-(4-fluorophenyl)-6-fluoro-quinolin-4-yl)-1,3,4-oxadiazole-2-thiol 
• 1596354-67-4 N-(4-chlorophenyl)-5-(6-fluoro-2-(4-fluorophenyl)quinolin-4-yl)-4H-1,2,4-triazol-3-amine 
• 1596354-68-5 N-(4-bromophenyl)-5-(6-fluoro-2-(4-fluorophenyl)quinolin-4-yl)-4H-1,2,4-triazol-3-amine 
• 1596354-69-6 N-(p-tolyl)-5-(6-fluoro-2-(4-fluorophenyl)quinolin-4-yl)-4H-1,2,4-triazol-3-amine 
• 1596354-70-9 N-(4-methoxyphenyl)-5-(6-fluoro-2-(4-fluorophenyl)quinolin-4-yl)-4H-1,2,4-triazol-3-amine 
• 1596354-71-0 1-(2-(4-fluorophenyl)-6-fluoroquinolin-4-carbonyl)-3,5-dimethyl-1H-pyrazole 
• 1596354-72-1 1-(2-(4-fluorophenyl)-6-fluoroquinolin-4-carbonyl)-3-methyl-5-phenyl-1H-pyrazole 

Relevant articles and documents

Synthesis, molecular modeling and anti-inflammatory screening of novel fluorinated quinoline incorporated benzimidazole derivatives using the Pfitzinger reaction

Several new fluorinated quinoline derivatives were synthesized and tested for their anti-inflammatory and ulcerogenic effect. A docking study on the COX-2 binding pocket was carried out for the target compounds to rationalize the possible selectivity of them against COX-2 enzyme. The most active compounds (3, 2, 7 and 11) were found to be superior to celecoxib as they were devoid of any ulcerogenic activity. Compound 3a demonstrated the highest anti-inflammatory activity as well as the best binding profiles into the COX-2 binding site. Moreover, compounds 3-12 were screened for antibacterial activity and none of them showed noteworthy activity.