Technology Process of 1-(3,5-bis(trifluoromethyl)benzyloxy)-4-amino-2-methyl-2-(phenyl)butane
There total 6 articles about 1-(3,5-bis(trifluoromethyl)benzyloxy)-4-amino-2-methyl-2-(phenyl)butane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(3,5-bis(trifluoromethyl)benzyloxy)-3-methyl-3-phenylbutanenitrile;
With
dimethylsulfide borane complex;
at 20 - 80 ℃;
for 1.5 - 2h;
Neat liquid(s);
With
methanol;
at 80 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / -20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 1 h
3.1: pyridine / dichloromethane / -20 - 20 °C
4.1: water; dimethyl sulfoxide / 100 °C
5.1: dimethylsulfide borane complex / tetrahydrofuran / 1.5 h / 80 °C / Neat liquid(s)
5.2: 1 h / 80 °C
With
pyridine; lithium aluminium tetrahydride; dimethylsulfide borane complex; sodium hydride;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 1 h
2.1: pyridine / dichloromethane / -20 - 20 °C
3.1: water; dimethyl sulfoxide / 100 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 1.5 h / 80 °C / Neat liquid(s)
4.2: 1 h / 80 °C
With
pyridine; dimethylsulfide borane complex; sodium hydride;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
