(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)-1-methyl-1H-pyrrol-2-yl)acrylic acid

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Chemical Name:(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)-1-methyl-1H-pyrrol-2-yl)acrylic acid
CAS No.:1401463-58-8
Molecular Formula:C₃₁H₂₆N₄O₂
Molecular Weight:486.573
Hs Code.:

Synonyms:(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)-1-methyl-1H-pyrrol-2-yl)acrylic acid

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Chemical Property of (2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)-1-methyl-1H-pyrrol-2-yl)acrylic acid

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Technology Process of (2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)-1-methyl-1H-pyrrol-2-yl)acrylic acid

There total 5 articles about (2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)-1-methyl-1H-pyrrol-2-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1416369-39-5
C₂₈H₂₅N₃O

: 372-09-8
cyanoacetic acid

: 1401463-58-8
(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)-1-methyl-1H-pyrrol-2-yl)acrylic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.dyepig.2012.09.001

Reference yield:

: 126496-49-9
1-methyl-2-isobutyrylpyrrole

: 1401463-58-8
(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)-1-methyl-1H-pyrrol-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / 85 °C

2.1: N-iodo-succinimide / tetrahydrofuran / 4 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C

3.2: 3 h / -78 - 20 °C

4.1: XPhos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 24 h / Reflux

5.1: 3 h / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-iodo-succinimide; n-butyllithium; caesium carbonate; toluene-4-sulfonic acid; sodium t-butanolate; XPhos; In tetrahydrofuran; toluene; 1.1: |Fischer Indole Synthesis;
DOI:10.1039/c2jm33228k

Reference yield:

: 1416369-36-2
C₁₅H₁₅BrN₂

: 1401463-58-8
(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)-1-methyl-1H-pyrrol-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-iodo-succinimide / tetrahydrofuran / 4 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C

2.2: 3 h / -78 - 20 °C

3.1: XPhos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 24 h / Reflux

4.1: 3 h / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-iodo-succinimide; n-butyllithium; caesium carbonate; sodium t-butanolate; XPhos; In tetrahydrofuran; toluene;
DOI:10.1039/c2jm33228k