4-cyclopropyl-N-[3-(4-fluorophenoxy)-5-(hydroxymethyl)phenyl]-4-hydroxy-1-piperidinecarboxamide

Base Information

Chemical Name:4-cyclopropyl-N-[3-(4-fluorophenoxy)-5-(hydroxymethyl)phenyl]-4-hydroxy-1-piperidinecarboxamide
CAS No.:1428901-27-2
Molecular Formula:C₂₂H₂₅FN₂O₄
Molecular Weight:400.45
Hs Code.:

Synonyms:4-cyclopropyl-N-[3-(4-fluorophenoxy)-5-(hydroxymethyl)phenyl]-4-hydroxy-1-piperidinecarboxamide

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Chemical Property of 4-cyclopropyl-N-[3-(4-fluorophenoxy)-5-(hydroxymethyl)phenyl]-4-hydroxy-1-piperidinecarboxamide

Chemical Property:

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Technology Process of 4-cyclopropyl-N-[3-(4-fluorophenoxy)-5-(hydroxymethyl)phenyl]-4-hydroxy-1-piperidinecarboxamide

There total 1 articles about 4-cyclopropyl-N-[3-(4-fluorophenoxy)-5-(hydroxymethyl)phenyl]-4-hydroxy-1-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428901-32-9
methyl 3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzoate

: 1428901-27-2
4-cyclopropyl-N-[3-(4-fluorophenoxy)-5-(hydroxymethyl)phenyl]-4-hydroxy-1-piperidinecarboxamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 0 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1428901-27-2
4-cyclopropyl-N-[3-(4-fluorophenoxy)-5-(hydroxymethyl)phenyl]-4-hydroxy-1-piperidinecarboxamide

: 123342-40-5
methyl 2-(4-hydroxyphenyl)-2-methylpropanoate

: C₃₃H₃₇FN₂O₆

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; at 20 ℃;

Reference yield:

: 1428901-27-2
4-cyclopropyl-N-[3-(4-fluorophenoxy)-5-(hydroxymethyl)phenyl]-4-hydroxy-1-piperidinecarboxamide

: 123342-40-5
methyl 2-(4-hydroxyphenyl)-2-methylpropanoate

: 1428901-02-3
2-(4-{[3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzyl]oxy}phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / 20 °C

2: sodium hydroxide; water / methanol / 2 h / 45 °C

With di-isopropyl azodicarboxylate; water; triphenylphosphine; sodium hydroxide; In methanol;