2-(4-{[3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzyl]oxy}phenyl)-2-methylpropanoic acid

Base Information

Chemical Name:2-(4-{[3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzyl]oxy}phenyl)-2-methylpropanoic acid
CAS No.:1428901-02-3
Molecular Formula:C₃₂H₃₅FN₂O₆
Molecular Weight:562.638
Hs Code.:

Synonyms:2-(4-{[3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzyl]oxy}phenyl)-2-methylpropanoic acid

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Chemical Property of 2-(4-{[3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzyl]oxy}phenyl)-2-methylpropanoic acid

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Technology Process of 2-(4-{[3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzyl]oxy}phenyl)-2-methylpropanoic acid

There total 4 articles about 2-(4-{[3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzyl]oxy}phenyl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₇FN₂O₆

: 1428901-02-3
2-(4-{[3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzyl]oxy}phenyl)-2-methylpropanoic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 45 ℃; for 2h;

Reference yield:

: 109492-91-3
methyl 2-[4-(benzyloxy)phenyl]-2-methylpropanoate

: 1428901-02-3
2-(4-{[3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzyl]oxy}phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on carbon; hydrogen / methanol; ethyl acetate / 4 h / 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / 20 °C

3: sodium hydroxide; water / methanol / 2 h / 45 °C

With di-isopropyl azodicarboxylate; palladium on carbon; water; hydrogen; triphenylphosphine; sodium hydroxide; In methanol; ethyl acetate;

Reference yield:

: 1428901-32-9
methyl 3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzoate

: 1428901-02-3
2-(4-{[3-{[(4-cyclopropyl-4-hydroxy-1-piperidinyl)carbonyl]amino}-5-(4-fluorophenoxy)benzyl]oxy}phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / 0 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / 20 °C

3: sodium hydroxide; water / methanol / 2 h / 45 °C

With di-isopropyl azodicarboxylate; water; diisobutylaluminium hydride; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; toluene;