C₉H₈BrFO₃

Base Information

• Chemical Name: C₉H₈BrFO₃
• CAS No.: 1359857-76-3
• Molecular Formula: C₉H₈BrFO₃
• Molecular Weight: 263.063
• Mol file: 1359857-76-3.mol

Synonyms:C₉H₈BrFO₃

Chemical Property of C₉H₈BrFO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₈BrFO₃

There total 4 articles about C₉H₈BrFO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C9H7Br2FO2 (1359857-74-1) → C9H8BrFO3 (1359857-76-3)

Guidance literature:

With water; calcium carbonate; In 1,4-dioxane; at 100 ℃; for 16h;

DOI:10.1016/j.bmcl.2011.12.096

Reference yield:

2-bromo-6-fluoro-3-methylbenzaldehyde (154650-16-5) → C9H8BrFO3 (1359857-76-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 1 h / 20 °C

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 16 h / 82 °C / Inert atmosphere

4.1: water; calcium carbonate / 1,4-dioxane / 16 h / 100 °C

With sodium chlorite; N-Bromosuccinimide; 2-methyl-but-2-ene; sodium dihydrogenphosphate dihydrate; water; potassium carbonate; calcium carbonate; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2011.12.096

Reference yield:

2-bromo-6-fluoro-3-methylbenzoic acid methyl ester (1359857-62-7) → C9H8BrFO3 (1359857-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 16 h / 82 °C / Inert atmosphere

2: water; calcium carbonate / 1,4-dioxane / 16 h / 100 °C

With N-Bromosuccinimide; water; calcium carbonate; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane;

DOI:10.1016/j.bmcl.2011.12.096

upstream raw materials:

C₉H₇Br₂FO₂

2-bromo-6-fluoro-3-methylbenzaldehyde

2-bromo-6-fluoro-3-methylbenzoic acid methyl ester

2-bromo-4-fluorotoluene

Downstream raw materials:

C₉H₆BrFO₃

C₁₁H₁₀BrFO₄

C₁₇H₂₂BFO₆