2-bromo-1-(4-chloro-2-fluorophenyl)ethanone

Base Information

• Chemical Name: 2-bromo-1-(4-chloro-2-fluorophenyl)ethanone
• CAS No.: 725743-41-9
• Molecular Formula: C₈H₅BrClFO
• Molecular Weight: 251.483
• Hs Code.: 2914790090
• Mol file: 725743-41-9.mol

Synonyms:2-bromo-1-(4-chloro-2-fluorophenyl)ethen-1-one

Chemical Property of 2-bromo-1-(4-chloro-2-fluorophenyl)ethanone

Chemical Property:

• Boiling Point: 284.7±25.0 °C(Predicted)
• Density: 1.673±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-chlorophenacylbromide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-1-(4-chloro-2-fluorophenyl)ethanone

There total 2 articles about 2-bromo-1-(4-chloro-2-fluorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4’-chloro-2’-fluoroacetophenone (175711-83-8) → 2-bromo-1-(4-chloro-2-fluorophenyl)ethen-1-one (725743-41-9)

Guidance literature:

With 4-(dimethylamino)pyridine tribromide; In acetic acid; at 20 ℃; for 24h;

Reference yield:

→ 2-bromo-1-(4-chloro-2-fluorophenyl)ethen-1-one (725743-41-9)

Guidance literature:

Reference yield: 92.7%

4’-chloro-2’-fluoroacetophenone (175711-83-8) + 2-bromo-1-(4-chloro-2-fluorophenyl)ethen-1-one (725743-41-9) → 1,4-bis(4-chloro-2-fluorophenyl)-1,4-butanedione

Guidance literature:

With diethylamine; zinc(II) chloride; In toluene; tert-butyl alcohol; at 35 ℃; for 24h; Reagent/catalyst; Green chemistry;

upstream raw materials:

4’-chloro-2’-fluoroacetophenone

Downstream raw materials:

2-(4-(4-chloro-2-fluorophenyl)thiazol-2-yl)-1-(3-phenylisoquinolin-1-yl)hydrazine

5-(4-chloro-2-fluorophenyl)-2-(thiophen-2-yl)oxazole

C₈H₇ClFNO

2-amino-1-(4-chloro-2-fluorophenyl)ethanone hydrochloride

Refernces

• 1、 -. "Synthetic method of pibrentasvir intermediate". Paragraph 0036-0039. . Retrieved 2019/04/30.
• 2、 -. "COMPOSITIONS AND METHODS FOR IMPROVING AGRONOMIC CHARACTERISTICS OF PLANTS". Paragraph 0399. . Retrieved 2016/07/05.