5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine

Base Information

Chemical Name:5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine
CAS No.:152343-98-1
Molecular Formula:C₄₁H₅₁N₅O₇Si
Molecular Weight:753.971
Hs Code.:

Synonyms:5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine

Suppliers and Price of 5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Hazard Codes:

MSDS Files:

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Technology Process of 5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine

There total 2 articles about 5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68892-41-1
5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 152343-98-1
5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine

Guidance literature:: With n-butyllithium; Multistep reaction; 1.) THF, -20 deg C, 20 min, 2.) THF, RT, 2 h;

Reference yield:

: 68892-42-2
N-isobutyryl-2'-deoxyguanosine

: 152343-98-1
5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; dmap; triethylamine / 4 h / 20 °C

2: pyridine; silver nitrate / tetrahydrofuran / 20 °C

With pyridine; dmap; silver nitrate; triethylamine; In tetrahydrofuran;
DOI:10.1039/c2ob06934b

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 152343-98-1
5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine

: 5’-O-DMT-3’-O-tertbutyldimethylsilyl-N2-(tert-butyloxycarbonyl)-2'-deoxyguanosine

Guidance literature:: 5’-O-(4,4’dimethoxytrityl)-N2-(isobutyryl)-3’-O-tert-butyldimethylsilyl-2'-deoxyguanosine; With ammonia; In methanol; water;

With potassium carbonate; In tetrahydrofuran; for 0.166667h;

di-tert-butyl dicarbonate; In tetrahydrofuran; for 3h;