1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one

Base Information

Chemical Name:1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one
CAS No.:115920-42-8
Molecular Formula:C₁₆H₁₇NO₄
Molecular Weight:287.315
Hs Code.:
DSSTox Substance ID:DTXSID80921865
Nikkaji Number:J936.805A
Wikidata:Q82895004
Mol file:115920-42-8.mol

Synonyms:carbazomycin H

Suppliers and Price of 1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CARBAZOMYCIN H 95.00%
5MG
$ 500.01

Total 1 raw suppliers

Chemical Property of 1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one

Chemical Property:

Vapor Pressure:8.32E-13mmHg at 25°C
Boiling Point:547.2°C at 760 mmHg
Flash Point:284.7°C
PSA：71.55000
Density:1.33g/cm³
LogP:2.50070
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:287.11575802
Heavy Atom Count:21
Complexity:489

Purity/Quality:: CARBAZOMYCIN H 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=O)C2=C(C1(C)O)NC3=C2C=C(C=C3)OC)OC

Technology Process of 1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one

There total 12 articles about 1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 917-54-4
methyllithium

: 192188-92-4
3,6-dimethoxy-2-methyl-9H-carbazole-1,4-quinone

: 115920-42-8
1,4-dihydro-1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one

: 6-methoxy-2,3-dimethyl-9H-carbazole-1,4-quinone

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 6h; Further Variations:; Temperatures; reaction times, molar ratios; Product distribution;
DOI:10.1002/ejoc.200390116

Reference yield: 41.0%

: 917-54-4
methyllithium

: 192188-92-4
3,6-dimethoxy-2-methyl-9H-carbazole-1,4-quinone

: 115920-42-8
1,4-dihydro-1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one

Guidance literature:: In tetrahydrofuran; at -78 - 25 ℃;
DOI:10.1016/S0040-4039(97)00826-5

Reference yield:

: 96502-90-8
acetic acid 2,4-dimethoxy-3-methyl-phenyl ester

: 115920-42-8
1,4-dihydro-1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / aq. KOH / ethanol / 1 h / 25 °C

2: 90 percent / (NH₄)2Ce(NO₃)6 / acetonitrile; H₂O / 0.5 h / 0 °C

3: 83 percent / methanol / 1 h / 25 °C

4: 73 percent / Cu(OAc)2 / Pd(OAc)2 / acetic acid / 19 h / 117 °C

5: 41 percent / tetrahydrofuran / -78 - 25 °C

With potassium hydroxide; copper diacetate; ammonium cerium(IV) nitrate; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; acetic acid; acetonitrile;