4-[2-chloro-6-((2-fluorophenylsulfonyl)methyl)pyrimidin-4-yl]morpholine

Base Information

Chemical Name:4-[2-chloro-6-((2-fluorophenylsulfonyl)methyl)pyrimidin-4-yl]morpholine
CAS No.:1616974-39-0
Molecular Formula:C₁₅H₁₅ClFN₃O₃S
Molecular Weight:371.82
Hs Code.:

Synonyms:4-[2-chloro-6-((2-fluorophenylsulfonyl)methyl)pyrimidin-4-yl]morpholine

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Chemical Property of 4-[2-chloro-6-((2-fluorophenylsulfonyl)methyl)pyrimidin-4-yl]morpholine

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Technology Process of 4-[2-chloro-6-((2-fluorophenylsulfonyl)methyl)pyrimidin-4-yl]morpholine

There total 4 articles about 4-[2-chloro-6-((2-fluorophenylsulfonyl)methyl)pyrimidin-4-yl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 127159-66-4
sodium 2-fluorobenzenesulfinate

: 1101818-26-1
4-[2-chloro-6-(iodomethyl)pyrimidin-4-yl]morpholine

: 1616974-39-0
4-[2-chloro-6-((2-fluorophenylsulfonyl)methyl)pyrimidin-4-yl]morpholine

Guidance literature:: In N,N-dimethyl-formamide; at 25 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.04.111

Reference yield:

: 2905-21-7
2-fluorobenzenesulfonyl chloride

: 1616974-39-0
4-[2-chloro-6-((2-fluorophenylsulfonyl)methyl)pyrimidin-4-yl]morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; sodium sulfite / water / 2 h / 50 °C

2: N,N-dimethyl-formamide / 2 h / 25 °C / Inert atmosphere

With sodium carbonate; sodium sulfite; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2014.04.111

Reference yield:

: 107973-01-3
Methyl Ester of 6-Morpholino-2-chloropyrimidine-4-carboxylic acid

: 1616974-39-0
4-[2-chloro-6-((2-fluorophenylsulfonyl)methyl)pyrimidin-4-yl]morpholine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran / 24 h / 22 °C

2.1: triethylamine; N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 1 h / 20 °C

2.2: 20 - 90 °C

3.1: N,N-dimethyl-formamide / 2 h / 25 °C / Inert atmosphere

With lithium borohydride; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2014.04.111