2-Fluorobenzenesulfonyl chloride

Base Information

• Chemical Name: 2-Fluorobenzenesulfonyl chloride
• CAS No.: 2905-21-7
• Molecular Formula: C6H4ClFO2S
• Molecular Weight: 194.614
• Hs Code.: 29049090
• Mol file: 2905-21-7.mol

Synonyms:Benzenesulfonylchloride, o-fluoro- (7CI);2-Fluorobenzene-1-sulfonyl chloride;o-Fluorobenzenesulfonyl chloride;

Chemical Property of 2-Fluorobenzenesulfonyl chloride

Chemical Property:

• Appearance/Colour: clear colorless to yellow liquid
• Vapor Pressure: 2.09E-05mmHg at 25°C
• Melting Point: 27-30 °C(lit.)
• Refractive Index: n20/D 1.537(lit.)
• Boiling Point: 242 °C at 760 mmHg
• Flash Point: 100.2 °C
• PSA: 42.52000
• Density: 1.493 g/cm³
• LogP: 2.83400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2-Fluorobenzenesulfonyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Fluorobenzenesulfonyl chloride may be used in the preparation of the following furan derivatives:2-(2-fluorophenyl)benzofuran2-butyl-5-(2-fluorophenyl)furan2-(2-fluorophenyl)-3,6-dimethyl-4,5,6,7-tetrahydrobenzofuranIt may also be used to prepare:2-fluorobenzenesulfonamidemethyl 2-{[(2-fluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylatepotassium fluorobenzene-2-sulfonate1-(2-bromobenzyl)-2-(2-fluorophenyl)pyrrole

Technology Process of 2-Fluorobenzenesulfonyl chloride

There total 3 articles about 2-Fluorobenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-fluorothiophenol (2557-78-0) → 2-fluorobenzenesulfonyl chloride (2905-21-7)

Guidance literature:

With ammonium nitrate; hydrogenchloride; oxygen; In water; acetonitrile; at 60 ℃; for 2h; Green chemistry;

DOI:10.1039/c7gc00556c

Reference yield:

2-Fluoroaniline (348-54-9) → 2-fluorobenzenesulfonyl chloride (2905-21-7)

Guidance literature:

Multistep reaction; (i) NaNO₂, aq. HCl, (ii) SO₂, CuCl₂, KCl, benzene, dioxane;

Reference yield:

→ 2-fluorobenzenesulfonyl chloride (2905-21-7)

Guidance literature:

upstream raw materials:

2-Fluoroaniline

2-fluorothiophenol

Downstream raw materials:

2-tert-butoxycarbonylamino-6-(2-fluoro-benzenesulfonylamino)-hexanoic acid

benzyl 2-(6-chloro-9-(2-fluorophenylsulfonyl)-9H-carbazol-2-yl)propanoate

Refernces

• 1、 -. "Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists". . . Retrieved 2008/06/13.
• 2、 -. "Polymer electrolyte and process for producing the same". . . Retrieved 2008/06/13.