6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid

Base Information

Chemical Name:6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid
CAS No.:1636166-31-8
Molecular Formula:C₁₃H₈ClF₃N₂O₂
Molecular Weight:316.667
Hs Code.:

Synonyms:6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid

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Chemical Property of 6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid

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Technology Process of 6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid

There total 3 articles about 6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1636166-30-7
methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate

: 1636166-31-8
6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 7h;
DOI:10.5935/0103-5053.20140073

Reference yield:

: 1112178-31-0
methyl-6-chloro-2-methylpyrimidine-4-carboxylate

: 1636166-31-8
6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane; water / 18 h / 80 °C / Inert atmosphere

2: potassium acetate; trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane; water / 6 h / Inert atmosphere; Heating

3: sodium hydroxide / water; tetrahydrofuran / 7 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; trans-bis(triphenylphosphine)palladium dichloride; potassium acetate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.5935/0103-5053.20140073

Reference yield:

: 1636166-29-4
methyl 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-4-carboxylate

: 1636166-31-8
6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane; water / 6 h / Inert atmosphere; Heating

2: sodium hydroxide / water; tetrahydrofuran / 7 h / 20 °C

With trans-bis(triphenylphosphine)palladium dichloride; potassium acetate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.5935/0103-5053.20140073