methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate

Base Information

Chemical Name:methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate
CAS No.:1636166-30-7
Molecular Formula:C₁₄H₁₀ClF₃N₂O₂
Molecular Weight:330.694
Hs Code.:

Synonyms:methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate

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Chemical Property of methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate

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Technology Process of methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate

There total 2 articles about methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 344-65-0
1-bromo-4-chloro-2-(trifluoromethyl)benzene

: 1636166-29-4
methyl 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-4-carboxylate

: 1636166-30-7
methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate

Guidance literature:: With trans-bis(triphenylphosphine)palladium dichloride; potassium acetate; In 1,4-dioxane; water; for 6h; Inert atmosphere; Heating;
DOI:10.5935/0103-5053.20140073

Reference yield:

: 1112178-31-0
methyl-6-chloro-2-methylpyrimidine-4-carboxylate

: 1636166-30-7
methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane; water / 18 h / 80 °C / Inert atmosphere

2: potassium acetate; trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane; water / 6 h / Inert atmosphere; Heating

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; trans-bis(triphenylphosphine)palladium dichloride; potassium acetate; In 1,4-dioxane; water;
DOI:10.5935/0103-5053.20140073