(R,S)-N-[2-(3,4-dimethoxyphenyl)-2-methylaminoethyl]pyrrolidine

Base Information

• Chemical Name: (R,S)-N-[2-(3,4-dimethoxyphenyl)-2-methylaminoethyl]pyrrolidine
• CAS No.: 115201-11-1
• Molecular Formula: C₁₅H₂₄N₂O₂
• Molecular Weight: 264.368
• Mol file: 115201-11-1.mol

Synonyms:(R,S)-N-[2-(3,4-dimethoxyphenyl)-2-methylaminoethyl]pyrrolidine

Chemical Property of (R,S)-N-[2-(3,4-dimethoxyphenyl)-2-methylaminoethyl]pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,S)-N-[2-(3,4-dimethoxyphenyl)-2-methylaminoethyl]pyrrolidine

There total 4 articles about (R,S)-N-[2-(3,4-dimethoxyphenyl)-2-methylaminoethyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(3,4-Dimethoxy-phenyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-carbamic acid methyl ester (115201-10-0) → (R,S)-N-[2-(3,4-dimethoxyphenyl)-2-methylaminoethyl]pyrrolidine (115201-11-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm00115a001

Reference yield:

1,2-dimethoxybenzene (91-16-7) → (R,S)-N-[2-(3,4-dimethoxyphenyl)-2-methylaminoethyl]pyrrolidine (115201-11-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 27 percent / AcOH, H₂SO₄ / 16 h

2: 1.) carbonyldiimidazole / 1.) EtOAc, 10-15 deg C, 2 h, 2.) EtOAc, 1 h

3: LAH / tetrahydrofuran / 16 h / 20 °C

With lithium aluminium tetrahydride; sulfuric acid; acetic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran;

DOI:10.1021/jm00115a001

Reference yield:

N-(methoxycarbonyl)-(R,S)-(3,4-dimethoxyphenyl)glycine (115201-12-2) → (R,S)-N-[2-(3,4-dimethoxyphenyl)-2-methylaminoethyl]pyrrolidine (115201-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) carbonyldiimidazole / 1.) EtOAc, 10-15 deg C, 2 h, 2.) EtOAc, 1 h

2: LAH / tetrahydrofuran / 16 h / 20 °C

With lithium aluminium tetrahydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran;

DOI:10.1021/jm00115a001

upstream raw materials:

[1-(3,4-Dimethoxy-phenyl)-2-oxo-2-pyrrolidin-1-yl-ethyl]-carbamic acid methyl ester

1,2-dimethoxybenzene

N-(methoxycarbonyl)-(R,S)-(3,4-dimethoxyphenyl)glycine

Downstream raw materials:

2-(3,4-Dichloro-phenyl)-N-[1-(3,4-dimethoxy-phenyl)-2-pyrrolidin-1-yl-ethyl]-N-methyl-acetamide