Technology Process of N-(2-ethoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide
There total 11 articles about N-(2-ethoxy-8-methyl-7-((1-methylpiperidin-4-yl)oxy)quinolin-3-yl)-3',6-dimethoxy-[1,1'-biphenyl]-3-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
DOI:10.1016/j.bmc.2013.12.056
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
3: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C
4: trimethylsilylazide; ethanolamine / N,N-dimethyl acetamide / 6 h / 95 °C / Sealed tube
5: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C
6: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h
7: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
With
pyridine; N-Bromosuccinimide; trimethylsilylazide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; potassium carbonate; ethanolamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
7: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.12.056
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
2: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C
3: trimethylsilylazide; ethanolamine / N,N-dimethyl acetamide / 6 h / 95 °C / Sealed tube
4: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 20 °C
5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h
6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
With
pyridine; N-Bromosuccinimide; trimethylsilylazide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; potassium carbonate; ethanolamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;
6: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2013.12.056
