4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide

Base Information

Chemical Name:4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide
CAS No.:957999-31-4
Molecular Formula:C₁₉H₁₈F₃N₅O₃S
Molecular Weight:453.445
Hs Code.:

Synonyms:4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide

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Chemical Property of 4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide

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Technology Process of 4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide

There total 1 articles about 4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 957999-32-5
4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carbonyl chloride

: 957999-31-4
4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide

Guidance literature:: 7-methoxythiazolo[5,4-d]pyrimidin-2-amine; With sodium hydride; In tetrahydrofuran; at 25 - 50 ℃; for 1h;

4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carbonyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 25 ℃;

With hydrogenchloride; water; In ethyl acetate;

Reference yield: 67.0%

: 957999-31-4
4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide

: 107-14-2
chloroacetonitrile

: 957999-67-6
4-(2-chloro-acetylamino)-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide

Guidance literature:: 4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide; chloroacetonitrile; With sulfuric acid; acetic acid; at 0 - 25 ℃; for 2h; Ultrasonic;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 28.0%

: 957999-31-4
4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide

: 75-05-8,26809-02-9
acetonitrile

: 4-acetylamino-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide

Guidance literature:: 4-hydroxy-4-(3-trifluoromethyl-phenyl)-piperidine-1-carboxylic acid (7-methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-amide; acetonitrile; With sulfuric acid; acetic acid; at 0 - 25 ℃; for 2h;

With sodium hydrogencarbonate; In water;