methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

Base Information

Chemical Name:methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate
CAS No.:1262007-92-0
Molecular Formula:C₂HF₃O₂*C₂₅H₂₇N₃O₄
Molecular Weight:547.531
Hs Code.:

Synonyms:methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

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Chemical Property of methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

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Technology Process of methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

There total 6 articles about methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262007-90-8
tert-butyl 6-(3-cyano-4-isopropoxybenzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

: 76-05-1
trifluoroacetic acid

: 1262007-92-0
methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

Guidance literature:: In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 52055-23-9
5-benzyloxytryptamine hydrochloride

: 1262007-92-0
methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid; water / methanol / 80 °C

2: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C

3: triethylamine / 1,4-dioxane / 2 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 20 °C

5: dichloromethane / 1 h / 0 °C

With water; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; 10% palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1262007-84-0
methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate

: 1262007-92-0
methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C

2: triethylamine / 1,4-dioxane / 2 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C

4: dichloromethane / 1 h / 0 °C

With hydrogen; caesium carbonate; triethylamine; 10% palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;