methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

Base Information

• Chemical Name: methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate
• CAS No.: 1262007-92-0
• Molecular Formula: C₂HF₃O₂*C₂₅H₂₇N₃O₄
• Molecular Weight: 547.531
• Mol file: 1262007-92-0.mol

Synonyms:methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

Chemical Property of methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate

There total 6 articles about methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 6-(3-cyano-4-isopropoxybenzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1262007-90-8) + trifluoroacetic acid (76-05-1) → methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate (1262007-92-0)

Guidance literature:

In dichloromethane; at 0 ℃; for 1h;

Reference yield:

5-benzyloxytryptamine hydrochloride (52055-23-9) → methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate (1262007-92-0)

Guidance literature:

Multi-step reaction with 5 steps

1: trifluoroacetic acid; water / methanol / 80 °C

2: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C

3: triethylamine / 1,4-dioxane / 2 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 20 °C

5: dichloromethane / 1 h / 0 °C

With water; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; 10% palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate (1262007-84-0) → methyl 2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate 2,2,2-trifluoroacetate (1262007-92-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen / 10% palladium on activated charcoal / tetrahydrofuran; methanol / 1 h / 20 °C

2: triethylamine / 1,4-dioxane / 2 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C

4: dichloromethane / 1 h / 0 °C

With hydrogen; caesium carbonate; triethylamine; 10% palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 6-(3-cyano-4-isopropoxybenzyloxy)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

trifluoroacetic acid

5-benzyloxytryptamine hydrochloride

methyl 2-(6-(benzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate

Downstream raw materials:

2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid

(S)-2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid

(R)-2-(6-(3-cyano-4-isopropoxybenzyloxy)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetic acid