2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl chloride

Base Information

• Chemical Name: 2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl chloride
• CAS No.: 49617-20-1
• Molecular Formula: C₂₇H₂₇ClO₄
• Molecular Weight: 450.962
• Mol file: 49617-20-1.mol

Synonyms:2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl chloride

Chemical Property of 2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl chloride

There total 4 articles about 2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2,3-O-isopropylidene-5-O-trityl-D-ribofuranose (54503-64-9,54503-65-0) → 2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl chloride (49617-20-1)

Guidance literature:

With Dimethyltrichloromethylamine; triethylamine; In dichloromethane; for 3h; Heating;

Reference yield:

2,3-O-isopropylidene-D-ribofuranose (67814-68-0,70266-87-4,76249-50-8,76249-51-9,93451-15-1,4099-88-1) → 2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl chloride (49617-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / pyridine / 24 h / 25 °C

2: 52 percent / triethylamine, (CH₃)2NCCl₃ / CH₂Cl₂ / 3 h / Heating

With pyridine; Dimethyltrichloromethylamine; triethylamine; In dichloromethane;

Reference yield:

D-Ribose (532-20-7,613-83-2,7261-25-8,7687-39-0,13221-22-2,14795-83-6,15761-67-8,20074-49-1,25545-03-3,25545-04-4,32445-75-3,34436-17-4,36441-93-7,36468-53-8,37110-85-3,37388-49-1,38029-69-5,40461-77-6,40461-89-0,41546-19-4,41546-20-7,41546-21-8,41546-26-3,41546-29-6,41546-30-9,41546-31-0,126872-16-0,131064-98-7) → 2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl chloride (49617-20-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 percent / H₂SO₄, CuSO₄ / 24 h / 25 °C

2: 88 percent / pyridine / 24 h / 25 °C

3: 52 percent / triethylamine, (CH₃)2NCCl₃ / CH₂Cl₂ / 3 h / Heating

With pyridine; Dimethyltrichloromethylamine; sulfuric acid; copper(II) sulfate; triethylamine; In dichloromethane;

upstream raw materials:

2,3-O-isopropylidene-5-O-trityl-D-ribofuranose

2,3-O-isopropylidene-D-ribofuranose

D-Ribose

trityl chloride

Downstream raw materials:

2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl azide

1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

5-chloromethyl-1-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)-1,2,3-triazide

7-((3aR,4S,6R,6aR)-2,2-Dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-3-methoxymethyl-5-methyl-2-methylsulfanyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one