1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

Base Information

Chemical Name:1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole
CAS No.:163593-01-9
Molecular Formula:C₃₅H₄₃N₃O₅SSi
Molecular Weight:645.895
Hs Code.:

Synonyms:1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

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Technology Process of 1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

There total 1 articles about 1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78162-58-0
N,N-dimethyl-1H-imidazole-1-sulfonamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 49617-20-1
2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl chloride

: 163593-01-9
1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction;
DOI:10.1248/cpb.43.152

Reference yield: 80.0%

: 163593-01-9
1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

: 1-N,N-dimethylsulfamoyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1248/cpb.43.152

Reference yield:

: 107-30-2
chloromethyl methyl ether

: 163593-01-9
1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

: 1-N,N-dimethylsulfamoyl-2-tert-butyldimethylsilyl-5-(3-O-methoxymethyl-5-O-trityl-2-deoxy-D-erythro-pent-1-enofuranosyl)-1H-imidazole

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, RT, 2.5 h;
DOI:10.1248/cpb.43.152