4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluorobenzamide

Base Information

Chemical Name:4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluorobenzamide
CAS No.:1402582-01-7
Molecular Formula:C₁₉H₁₄ClF₄N₅O₂
Molecular Weight:455.799
Hs Code.:

Synonyms:4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluorobenzamide

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Chemical Property of 4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluorobenzamide

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Technology Process of 4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluorobenzamide

There total 5 articles about 4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1402582-08-4
4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid

: 1402582-01-7
4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluorobenzamide

Guidance literature:: With ammonia; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; at 23 ℃; for 2h;

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 1402582-01-7
4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / Reflux

2: palladium on activated charcoal; hydrogen / methanol / 2 h / 23 °C

3: dmap / acetonitrile / Reflux

4: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 40 °C

5: ammonia; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane; N,N-dimethyl-formamide / 2 h / 23 °C

With dmap; lithium hydroxide monohydrate; sulfuric acid; palladium on activated charcoal; ammonia; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 73792-08-2
methyl 4-amino-2-fluorobenzoate

: 1402582-01-7
4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / acetonitrile / Reflux

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 40 °C

3: ammonia; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1,4-dioxane; N,N-dimethyl-formamide / 2 h / 23 °C

With dmap; lithium hydroxide monohydrate; ammonia; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;