4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid

Base Information

Chemical Name:4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid
CAS No.:1402582-08-4
Molecular Formula:C₁₉H₁₃ClF₄N₄O₃
Molecular Weight:456.784
Hs Code.:

Synonyms:4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid

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Chemical Property of 4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid

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Technology Process of 4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid

There total 4 articles about 4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1402586-48-4
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-methyl]-3-[3-fluoro-4-(methoxycarbonyl)-phenyl]-urea

: 1402582-08-4
4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 40 ℃; for 2h;

Reference yield:

: 392-09-6
2-fluoro-4-nitro-benzoic acid methyl ester

: 1402582-08-4
4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; hydrogen / methanol / 2 h / 23 °C

2: dmap / acetonitrile / Reflux

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 40 °C

With dmap; lithium hydroxide monohydrate; palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; water; acetonitrile;

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 1402582-08-4
4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / Reflux

2: palladium on activated charcoal; hydrogen / methanol / 2 h / 23 °C

3: dmap / acetonitrile / Reflux

4: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 40 °C

With dmap; lithium hydroxide monohydrate; sulfuric acid; palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; water; acetonitrile;