1-propyl-7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine

Base Information

Chemical Name:1-propyl-7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine
CAS No.:886440-24-0
Molecular Formula:C₂₄H₃₂N₄O₇
Molecular Weight:488.541
Hs Code.:

Synonyms:1-propyl-7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine

Suppliers and Price of 1-propyl-7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-propyl-7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine

Chemical Property:

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Technology Process of 1-propyl-7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine

There total 7 articles about 1-propyl-7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 886440-19-3
7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine

: 107-08-4
1-iodo-propane

: 886440-24-0
1-propyl-7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 - 70 ℃; for 2h;
DOI:10.1016/j.bmc.2005.11.050

Reference yield:

: 5-(4-Methoxy-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine

: 886440-24-0
1-propyl-7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine

Guidance literature:: Multi-step reaction with 5 steps

1: 31 percent / sodium ethoxide / ethanol / 4 h / Heating

2: 58 percent / sodium dithionite / H₂O / 0.5 h / Heating

3: 88 percent / dimethylformamide / 4 h / Heating

4: 35 percent / potassium carbonate / dimethylformamide / 6 h / 60 - 70 °C

5: 72 percent / potassium carbonate / dimethylformamide / 2 h / 60 - 70 °C

With sodium dithionite; sodium ethanolate; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.050

Reference yield:

: 886439-94-7
5-amino-2-(4-methoxy-phenoxymethyl)-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one

: 886440-24-0
1-propyl-7-pivaloyloxymethyl-3-[2-hydroxy-3-(4-methoxyphenoxy)propyl]xanthine

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / sodium nitrite; acetic acid / H₂O / 1.5 h / 20 - 60 °C

2: 75 percent / sodium; ethanol / 8 h / Heating

3: 58 percent / sodium dithionite / H₂O / 0.5 h / Heating

4: 88 percent / dimethylformamide / 4 h / Heating

5: 35 percent / potassium carbonate / dimethylformamide / 6 h / 60 - 70 °C

6: 72 percent / potassium carbonate / dimethylformamide / 2 h / 60 - 70 °C

With sodium dithionite; ethanol; sodium; potassium carbonate; acetic acid; sodium nitrite; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.050