1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-phenylthiosemicarbazide

Base Information

• Chemical Name: 1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-phenylthiosemicarbazide
• CAS No.: 1374202-01-3
• Molecular Formula: C₂₂H₂₀N₆O₃S
• Molecular Weight: 448.505

Synonyms:1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-phenylthiosemicarbazide

Chemical Property of 1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-phenylthiosemicarbazide

Chemical Property:

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Technology Process of 1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-phenylthiosemicarbazide

There total 2 articles about 1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-phenylthiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-4(5H)-yl)acetohydrazide (1229043-23-5) + phenyl isothiocyanate (103-72-0) → 1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-phenylthiosemicarbazide (1374202-01-3)

Guidance literature:

In ethanol; for 4h; Reflux;

DOI:10.1016/j.bmc.2012.03.021

Reference yield:

7-benzyl-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one (129663-29-2) → 1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-phenylthiosemicarbazide (1374202-01-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 4 h / Reflux

1.2: 2 h / Reflux

2.1: hydrazine hydrate / ethanol / 1 h / Reflux

3.1: ethanol / 4 h / Reflux

With hydrazine hydrate; potassium carbonate; In ethanol; acetone;

DOI:10.1016/j.bmc.2012.03.021

Reference yield: 95.0%

1-(2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-5(4H)-yl)acetyl)-4-phenylthiosemicarbazide (1374202-01-3) → 7-benzyl-5-((4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one (1374202-21-7)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; water; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2012.03.021

upstream raw materials:

2-(7-benzyl-3-methyl-4-oxoisoxazolo[4,5-d]pyridazin-4(5H)-yl)acetohydrazide

phenyl isothiocyanate

7-benzyl-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one

Downstream raw materials:

7-benzyl-3-methyl-5-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)methyl)isoxazolo[4,5-d]pyridazin-4(5H)-one

7-benzyl-5-((4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-methylisoxazolo[4,5-d]pyridazin-4(5H)-one

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