N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(dimethylamino)ethoxy)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(dimethylamino)ethoxy)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide
CAS No.:1070295-32-7
Molecular Formula:C₂₉H₃₅N₃O₃
Molecular Weight:473.615
Hs Code.:

Synonyms:N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(dimethylamino)ethoxy)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

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Chemical Property of N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(dimethylamino)ethoxy)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

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Technology Process of N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(dimethylamino)ethoxy)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

There total 8 articles about N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(dimethylamino)ethoxy)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 1070295-34-9
N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-(hydroxymethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

: 1070295-32-7
N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(dimethylamino)ethoxy)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Guidance literature:: 2-(N,N-dimethylamino)ethanol; N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-(hydroxymethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide; With camphor-10-sulfonic acid; In dichloromethane; at 20 ℃; for 17h;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 66h;

Reference yield:

: 1070293-50-3
6-bromo-1-oxo-1H-isochromene-4-carboxylic acid methyl ester

: 1070295-32-7
N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(dimethylamino)ethoxy)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / methanol / 17 h / Heating / reflux

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 17 h / 80 °C

3.1: sodium hydroxide; water / methanol / 0.5 h / Heating / reflux

3.2: 20 °C

4.1: borane-THF / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: camphor-10-sulfonic acid / dichloromethane / 17 h / 20 °C

5.2: 66 h / 20 °C

With sodium hydroxide; borane-THF; camphor-10-sulfonic acid; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 943749-63-1
4-bromo-2-(carboxymethyl)benzoic acid

: 1070295-32-7
N-cyclopropyl-3-(2-(cyclopropylmethyl)-4-((2-(dimethylamino)ethoxy)methyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic anhydride / 2 h / 120 °C

2.1: methanol; sulfuric acid / 19 h / Heating / reflux

3.1: N-ethyl-N,N-diisopropylamine / methanol / 17 h / Heating / reflux

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 17 h / 80 °C

5.1: sodium hydroxide; water / methanol / 0.5 h / Heating / reflux

5.2: 20 °C

6.1: borane-THF / tetrahydrofuran / 2 h / 0 - 20 °C

7.1: camphor-10-sulfonic acid / dichloromethane / 17 h / 20 °C

7.2: 66 h / 20 °C

With methanol; sodium hydroxide; borane-THF; sulfuric acid; camphor-10-sulfonic acid; water; acetic anhydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;