(R,2E,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

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Chemical Name:(R,2E,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one
CAS No.:1501971-56-7
Molecular Formula:C₃₈H₆₅NO₈Si₂
Molecular Weight:720.107
Hs Code.:

(R,2E,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

Synonyms:(R,2E,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

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Chemical Property of (R,2E,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

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Technology Process of (R,2E,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

There total 11 articles about (R,2E,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(5-(4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)ethanone

: 1501971-55-6
(R,2E,4E)-6-((tert-butyldimethylsilyloxy)methyl)octa-2,4-dienal

: 1501971-56-7
(R,2E,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

: (R,2Z,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

Guidance literature:: 1-(5-(4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)ethanone; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

(R,2E,4E)-6-((tert-butyldimethylsilyloxy)methyl)octa-2,4-dienal; In tetrahydrofuran; at 0 - 20 ℃; Overall yield = 65 %; Overall yield = 46 mg; Inert atmosphere;
DOI:10.1021/ol402820d

Reference yield:

: 1501971-50-1
1-(2,4-bis(methoxymethoxy)pyridin-3-yl)ethanol

: 1501971-56-7
(R,2E,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

: (R,2Z,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sec.-butyllithium / tetrahydrofuran / 1 h / -60 °C / Inert atmosphere

1.2: 3 h / -60 - 20 °C / Inert atmosphere

2.1: Dess-Martin periodane; pyridine / dichloromethane / 3 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With pyridine; sec.-butyllithium; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol402820d

Reference yield:

: 1501971-48-7
2,4-bis(methoxymethoxy)pyridine

: 1501971-56-7
(R,2E,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

: (R,2Z,4E,6E)-1-(5-((1s,4S)-4-(tert-butyldimethylsilyloxy)-1-hydroxycyclohexyl)-2,4-bis(methoxymethoxy)pyridin-3-yl)-8-(tert-butyldimethylsilyloxymethyl)deca-2,4,6-trien-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: sec.-butyllithium / tetrahydrofuran / 1 h / -60 °C / Inert atmosphere

2.2: 3 h / -60 - 20 °C / Inert atmosphere

3.1: Dess-Martin periodane; pyridine / dichloromethane / 3 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With pyridine; tert.-butyl lithium; sec.-butyllithium; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol402820d