2,2,2-trifluoro-N-(4-fluoro-3-{1-[6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(4-fluoro-3-{1-[6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide
CAS No.:1268051-70-2
Molecular Formula:C₂₇H₂₈F₅N₃O₃
Molecular Weight:537.53
Hs Code.:

Synonyms:2,2,2-trifluoro-N-(4-fluoro-3-{1-[6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide

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Chemical Property of 2,2,2-trifluoro-N-(4-fluoro-3-{1-[6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide

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Technology Process of 2,2,2-trifluoro-N-(4-fluoro-3-{1-[6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide

There total 7 articles about 2,2,2-trifluoro-N-(4-fluoro-3-{1-[6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1067427-53-5
2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

: 1268051-69-9
6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carboxylic acid

: 1268051-70-2
2,2,2-trifluoro-N-(4-fluoro-3-{1-[6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide

Guidance literature:: 6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 - 40 ℃;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1268051-70-2
2,2,2-trifluoro-N-(4-fluoro-3-{1-[6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 20 - 80 °C / Inert atmosphere

1.2: 0.5 h / 20 °C

2.1: hydrogen / platinum on carbon / methanol / 48 h / 20 °C / 517.16 - 3102.97 Torr

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 20 °C

3.2: 20 - 40 °C

With hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1208977-19-8
2,2,2-trifluoro-N-(4-fluoro-3-pyridin-4-yl-benzyl)-acetamide hydrochloride

: 1268051-70-2
2,2,2-trifluoro-N-(4-fluoro-3-{1-[6-fluoro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carbonyl]piperidin-4-yl}benzyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / platinum on carbon / methanol / 48 h / 20 °C / 517.16 - 3102.97 Torr

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.33 h / 20 °C

2.2: 20 - 40 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; platinum on carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;