dracorhodin

Base Information

• Chemical Name: dracorhodin
• CAS No.: 643-56-1
• Molecular Formula: C17H14 O3
• Molecular Weight: 266.29
• Hs Code.: 2914509090
• Mol file: 643-56-1.mol

Synonyms:Anhydro-7-hydroxy-5-methoxy-6-methylflavenol;C.I. 75210; Dracorhodin; NSC 234485

Chemical Property of dracorhodin

Chemical Property:

• Vapor Pressure: 8.95E-13mmHg at 25°C
• Boiling Point: 564.7°C at 760 mmHg
• Flash Point: 288.1°C
• PSA: 39.44000
• Density: 1.23g/cm³
• LogP: 3.72860

Purity/Quality:

99% ^*data from raw suppliers

Dracorhodin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of dracorhodin

There total 10 articles about dracorhodin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenyl-5-methoxy-6-methyl-7-hydroxybenzopyran hydrochloride (1447-85-4) → 2-phenyl-5-methoxy-6-methyl-chromen-7-one (643-56-1)

Guidance literature:

With water; sodium hydrogencarbonate;

DOI:10.1039/jr9500001882

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) → 2-phenyl-5-methoxy-6-methyl-chromen-7-one (643-56-1)

Guidance literature:

Multi-step reaction with 9 steps

1.1: trichlorophosphate / 1 h / 0 °C

2.1: hydrazine hydrate / ethylene glycol / 3 h / 80 °C

2.2: 3 h / 120 °C

3.1: trichlorophosphate / 0 °C

4.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

5.1: potassium carbonate / acetone / 60 °C / Cooling with ice

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 60 °C / Cooling with ice

7.1: palladium on activated charcoal; hydrogen / ethyl acetate; methanol / 12 h / 20 °C / 760.05 - 3800.26 Torr

8.1: acetic acid; hydrogenchloride / 12 h / 20 °C

9.1: sodium acetate / methanol; water

With hydrogenchloride; palladium on activated charcoal; hydrogen; sodium acetate; boron tribromide; potassium carbonate; hydrazine hydrate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In methanol; dichloromethane; water; ethylene glycol; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

2,4,6-trimethoxybenzaldehyde (830-79-5) → 2-phenyl-5-methoxy-6-methyl-chromen-7-one (643-56-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: hydrazine hydrate / ethylene glycol / 3 h / 80 °C

1.2: 3 h / 120 °C

2.1: trichlorophosphate / 0 °C

3.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

4.1: potassium carbonate / acetone / 60 °C / Cooling with ice

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 60 °C / Cooling with ice

6.1: palladium on activated charcoal; hydrogen / ethyl acetate; methanol / 12 h / 20 °C / 760.05 - 3800.26 Torr

7.1: acetic acid; hydrogenchloride / 12 h / 20 °C

8.1: sodium acetate / methanol; water

With hydrogenchloride; palladium on activated charcoal; hydrogen; sodium acetate; boron tribromide; potassium carbonate; hydrazine hydrate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In methanol; dichloromethane; water; ethylene glycol; ethyl acetate; N,N-dimethyl-formamide; acetone;

upstream raw materials:

2-phenyl-5-methoxy-6-methyl-7-hydroxybenzopyran hydrochloride

acetophenone

1,2,3-trimethoxybenzene

2,4,6-trimethoxybenzaldehyde

Refernces