2,5-dioxopyrrolidin-1-yl 4,4-difluorocyclohexanecarboxylate

Base Information

• Chemical Name: 2,5-dioxopyrrolidin-1-yl 4,4-difluorocyclohexanecarboxylate
• CAS No.: 1369515-34-3
• Molecular Formula: C₁₁H₁₃F₂NO₄
• Molecular Weight: 261.225
• Mol file: 1369515-34-3.mol

Synonyms:2,5-dioxopyrrolidin-1-yl 4,4-difluorocyclohexanecarboxylate

Chemical Property of 2,5-dioxopyrrolidin-1-yl 4,4-difluorocyclohexanecarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of 2,5-dioxopyrrolidin-1-yl 4,4-difluorocyclohexanecarboxylate

There total 1 articles about 2,5-dioxopyrrolidin-1-yl 4,4-difluorocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4,4-difluorocyclohexanecarboxylic acid (122665-97-8) + 1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) → 2,5-dioxopyrrolidin-1-yl 4,4-difluorocyclohexanecarboxylate (1369515-34-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield: 45.0%

2,5-dioxopyrrolidin-1-yl 4,4-difluorocyclohexanecarboxylate (1369515-34-3) + (+/-)-6-(aminomethyl)-3-((3,4-trans)-1-benzyl-4-methylpyrrolidin-3-yl)-1,2,4-triazin-5(4H)-one → (+/-)-N-((3-((3,4-trans)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)-4,4-difluorocyclohexanecarboxamide

Guidance literature:

In dichloromethane; at 20 ℃;

Reference yield: 45.0%

2,5-dioxopyrrolidin-1-yl 4,4-difluorocyclohexanecarboxylate (1369515-34-3) + (±)-6-(aminomethyl)-3-((3,4-trans)-1-benzyl-4-methylpyrrolidin-3-yl)-1,2,4-triazin-5(4H)-one → (±)-N-((3-((3,4-trans)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)-4,4-difluorocyclohexanecarboxamide

Guidance literature:

In dichloromethane; at 20 ℃;

upstream raw materials:

4,4-difluorocyclohexanecarboxylic acid

1-hydroxy-pyrrolidine-2,5-dione