11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1 methyl ester

Base Information

• Chemical Name: 11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1 methyl ester
• CAS No.: 256382-18-0
• Molecular Formula: C₂₄H₃₄O₅S
• Molecular Weight: 434.597
• Mol file: 256382-18-0.mol

Synonyms:11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1 methyl ester

Chemical Property of 11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1 methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1 methyl ester

There total 2 articles about 11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1 methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C24H32O5S (443987-99-3) → 11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1 methyl ester (256382-18-0)

Guidance literature:

With copper(l) iodide; lithium aluminium tetrahydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 3h; Inert atmosphere;

DOI:10.1248/cpb.59.1494

Reference yield:

Rivenprost (256382-08-8) → 11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1 methyl ester (256382-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; acetic acid / water / 5 h / 80 °C / Inert atmosphere

2: copper(l) iodide; lithium aluminium tetrahydride / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 3 h / -78 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water;

DOI:10.1248/cpb.59.1494

Reference yield: 84.0%

11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1 methyl ester (256382-18-0) → 11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1 (256382-30-6)

Guidance literature:

In ethanol; at 20 ℃; for 2h; pH=7.4; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1248/cpb.59.1494

upstream raw materials:

C₂₄H₃₂O₅S

Rivenprost

Downstream raw materials:

11-deoxy-16-(3-methoxymethyl)phenyl-ω-tetranor-5-thiaPGE1