N-(9-{5-hydroxy-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohex-2-enyl}-9H-purin-6-yl)-benzamide

Base Information

Chemical Name:N-(9-{5-hydroxy-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohex-2-enyl}-9H-purin-6-yl)-benzamide
CAS No.:677757-94-7
Molecular Formula:C₃₉H₃₅N₅O₄
Molecular Weight:637.738
Hs Code.:

<i>N</i>-(9-{5-hydroxy-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohex-2-enyl}-9<i>H</i>-purin-6-yl)-benzamide

Synonyms:N-(9-{5-hydroxy-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohex-2-enyl}-9H-purin-6-yl)-benzamide

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Chemical Property of N-(9-{5-hydroxy-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohex-2-enyl}-9H-purin-6-yl)-benzamide

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Technology Process of N-(9-{5-hydroxy-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohex-2-enyl}-9H-purin-6-yl)-benzamide

There total 8 articles about N-(9-{5-hydroxy-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohex-2-enyl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (+/-)-(4aR,7R,8aS)-2-phenyl-4a,7,8,8a-tetrahydro-4H-benzo[d][1,3]dioxin-7-ol

: 677757-94-7
N-(9-{5-hydroxy-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohex-2-enyl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / DMAP; pyridine / 20 °C

2: porcine liver esterase; phosphate buffer / H₂O; 2-methyl-propan-2-ol / 10 h / 20 °C / pH 7.5

3: pyridine / 20 °C

4: trifluoroacetic acid / H₂O / 40 h

5: 618 mg / pyridine / 22 h / 0 - 20 °C

With pyridine; porcine liver esterase; dmap; phosphate buffer; trifluoroacetic acid; In water; tert-butyl alcohol; 3: Mitsunobu reaction;
DOI:10.1016/j.tet.2003.12.052

Reference yield:

: (+/-)-(4aR,7R,8aS)-2-phenyl-4a,7,8,8a-tetrahydro-4H-1,3-benzodioxin-7-yl acetate

: 677757-94-7
N-(9-{5-hydroxy-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohex-2-enyl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: Candida rugosa lipase; phosphate buffer / H₂O; 2-methyl-propan-2-ol / 24 h / 20 °C / pH 8.0

2: pyridine / 20 °C

3: trifluoroacetic acid / H₂O / 40 h

4: 618 mg / pyridine / 22 h / 0 - 20 °C

With pyridine; phosphate buffer; trifluoroacetic acid; Candida rugosa lipase; In water; tert-butyl alcohol; 2: Mitsunobu reaction;
DOI:10.1016/j.tet.2003.12.052

Reference yield:

: 98-88-4
benzoyl chloride

: 677757-94-7
N-(9-{5-hydroxy-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-cyclohex-2-enyl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 °C

2: trifluoroacetic acid / H₂O / 40 h

3: 618 mg / pyridine / 22 h / 0 - 20 °C

With pyridine; trifluoroacetic acid; In water;
DOI:10.1016/j.tet.2003.12.052