cis-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Base Information

Chemical Name:cis-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one
CAS No.:129151-99-1
Molecular Formula:C₁₈H₁₉NO₂
Molecular Weight:281.354
Hs Code.:

Synonyms:cis-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

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Chemical Property of cis-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

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Technology Process of cis-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

There total 19 articles about cis-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7443-25-6
dimethyl 2-(4-methoxybenzylidene)malonate

: 129151-99-1
cis-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / dimethylformamide / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

3: H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

4: MeONa / methanol / 3 h / Heating

5: LiBr / dimethylformamide / 4 h / Heating

With hydrogen; sodium methylate; sodium hydride; lithium bromide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00082a020

Reference yield:

: 129151-97-9
<1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester

: 129151-99-1
cis-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

2: MeONa / methanol / 3 h / Heating

3: LiBr / dimethylformamide / 4 h / Heating

With hydrogen; sodium methylate; lithium bromide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00082a020

Reference yield:

: 107967-05-5
[1-(4-Methoxyphenyl)-2-(2-nitrophenyl)ethyl]-propanedioic acid,dimethyl ester

: 129151-99-1
cis-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

2: H₂ / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr

3: MeONa / methanol / 3 h / Heating

4: LiBr / dimethylformamide / 4 h / Heating

With hydrogen; sodium methylate; sodium hydride; lithium bromide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00082a020